General description

A potent 5-HT_2A receptor antagonist (K_d = 26 nM), with moderate affinity for the alpha1-adrenergic receptor (K_d = 48 nM) and 5-HT_1A receptor (K_d = 80 nM). Originally developed as a clinical antidepressant but discontinued in 2004, nefazodone (Serzone) still remains a specific inhibitor of certain serotonergic pathways. Nefazodone also has been reported to induce mitochondrial dysfuntion.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Kim, J.-A. et al. 2012. Toxicol. Lett.214, 175.Cusack, B. et al. 1994. Psychopharmacol.114, 559.

Packaging

10 mg in Glass bottle

Warning

Toxicity: Standard Handling (A)